Endocrine Abstracts

Pituitary carcinomas are rare but represent a particular challenge to clinical practice. We report a case of pituitary carcinoma with metastatic disease in a separate non-contiguous foci within the central nervous system. A 64 year old man presented with a large non-functioning pituitary adenoma manifesting as headache, third pair of cranial nerves paralysis, panhypopituitarism and impaired visual acuity in 1996.The tumour was grossly removed through a right pterional cranioto...

IntroductionParathyroid carcinoma is a rare endocrine carcinoma, which represents less than 1% of all cases of primary hyperparathyroidism. It usually affects people between 44–55 years old without differences between sexes. Sometimes it is related to HRPT2 gene mutations and it has a variable prognosis.Presentation of caseA 56-year-old man was referred to our centre to complete an hypercalcemia study. H...

The picture showing a markedly virilised central figure with an infant at the breast and a shadowy figure in the background was painted in 1631 by Jose Ribera, a Spaniard living in Naples. It was commissioned by Ribera’s patron, the Duke of Alcela. The painting is of a real named person. The provenance of the painting is well known and through the Duke’s family inheritance it returned to Spain and is to be seen in the Muse Fondacion Duque de Lerma in Toledo. It can a...

Introduction: In May 2020, during the COVID-19 pandemic, the Spanish Group of Diabetes and Pregnancy published a consensus document establishing the alternative diagnostic criteria for gestational diabetes mellitus (GDM) in case of impossibility to perform the two-step traditional approach due to the COVID-19 sanitary emergency. This study aims to compare different characteristics of pregnant women who tested positive in the O’Sullivan test in the same pregnancy trimester...

Introduction: Overt thyroid dysfunction in pregnancy without an early diagnosis and treatment may lead to an increased risk of adverse maternal and fetal outcomes. In this study, our goal was to assess the results of the development of a laboratory alerting system for the diagnosis of thyroid dysfunction in the first trimester of pregnancy. Material and methods: Observational retrospective study evaluating clinical and biochemical data from pregnant wome...

Introduction and Objectives: Preperitoneal fat is an ectopic visceral adipose tissue with a significant proinflammatory metabolic impact. The objective of this study is to measure preperitoneal fat by nutritional ultrasound at discharge, 3 months and 6 months in a cohort of patients who required admission to the Intensive Care Unit (ICU) due to severe COVID-19 pneumonia, and to analyze the differences based on the presence or not of previous DM.Material ...

Introduction: Pregnancy in women with type 1 diabetes mellitus (T1DM) is associated with an increased risk of adverse outcomes, so pregnancy planning in order to achieve an optimal glycemic control is essential. This control has been made possible, in part, by the widespread use of insulin analogues, especially the long-acting ones, glargine and detemir. Insulin degludec, an ultra-long-acting insulin is not currently approved for pregnant women due to the lack of randomized co...

Introduction: The development of diabetes is common after pancreatic surgery, so a close follow-up is essential in order to make an early diagnosis and start treatment as soon as possible.Material and methods: Data from 56 patients subjected to pancreatic surgery between 2013 and 2018 are presented. Demographic and clinical-analytical characteristics are also described. We analyzed the incidence of diabetes during the follow-up (one month after surgery [...

Introduction: Different studies have published that testosterone therapy in men and women results in decreased HDL cholesterol and increased LDL cholesterol, and therefore an increased cardiovascular risk.Aims: To determine whether testosterone therapy has this effect on lipid parameters and markers of metabolic syndrome (MetSyn) in female-to-male transsexuals (FMT).Material and methods: We studied 50 FMT, aged 27.8±7.6 years,...

Two adipokines highly expressed in fat mass, adiponectin with antiinflammatory and antiatherogenic properties, and visfatin with an insulin-mimetic effect, are potential contributors to bone metabolism. In acromegaly data on adiponectin are contradictory and there are no data on visfatin.Objectives: To evaluate adiponectin and visfatin in acromegaly, compared to control subjects and to analyze their relationship with body composition and bone mineral mar...